Journal of Chemical Reviews

A Mini Review on Lactic Acidosis Effect, Cause, Symptoms, Complications, Metabolism, and Pathodology with Its Diagnosis, Treatment, and Preventions

Priya Kumari; Manish Singh Sengar; Neha Sengar

Volume 6, Issue 1 , January 2024, , Pages 27-38

https://doi.org/10.48309/jcr.2024.407092.1230

Abstract

Lactic acidosis is a condition characterized by an abnormal accumulation of lactic acid in the body, leading to a disturbance in the acid-base balance. It can occur due to various factors, ... Read More Lactic acidosis is a condition characterized by an abnormal accumulation of lactic acid in the body, leading to a disturbance in the acid-base balance. It can occur due to various factors, including impaired oxygen supply, medication use, and liver dysfunction. The pathophysiology of lactic acidosis involves an imbalance between lactic acid production and elimination or utilization. Diagnosing lactic acidosis involves clinical evaluation, blood tests, and identification of underlying causes. Elevated lactate levels, arterial blood gas analysis, and electrolyte imbalances are commonly assessed. Imaging studies and electrocardiograms may be used to evaluate organ function and identify contributing factors. Treatment of lactic acidosis focuses on addressing the underlying cause and supporting organ function. Prompt resuscitation and oxygen therapy are crucial in cases of impaired oxygen delivery. Medications or toxins that contribute to lactic acidosis may need to be discontinued or managed differently. Fluid and electrolyte management is essential for correcting imbalances and optimizing organ function. In severe cases, interventions such as renal replacement therapy or hemodialysis may be required. Prevention of lactic acidosis involves managing underlying medical conditions and avoiding factors that can contribute to its development. Regular monitoring of medications that can cause lactic acidosis is necessary, with adjustments made if needed. Proper control of chronic conditions such as diabetes or liver disease can minimize the risk of lactic acidosis. Individuals engaging in intense physical activities should receive appropriate training, hydration, and pacing to prevent excessive lactic acid build-up. Lactic acidosis can have significant health effects and complications. Cardiovascular effects can occur, including arrhythmias, decreased cardiac output, and cardiac arrest. Organ dysfunction, such as acute kidney injury, liver failure, and pancreatitis, may result from lactic acidosis. Metabolic acidosis, electrolyte imbalances, and hypoxia are also common consequences. In severe cases, lactic acidosis can lead to confusion, altered mental status, and coma.

The Design of Soft Drugs: Basic Principles, Energetic Metabolite Methods, Approved Compounds, and Pharmaceutical Applications

Babafakruddin Peddagundam; Hindustan Abdul Ahad; Haranath Chinthaginjala; Tarun Ksheerasagare; Aravind Kumar Ganthala; Govardhan Reddy Gummadisani

Volume 4, Issue 3 , June 2022, , Pages 241-254

https://doi.org/10.22034/jcr.2022.336306.1164

Abstract

This work explores soft drugs and their configuration for drug delivery. Compared with the stimulated soft compound, soft drugs have a fast metabolism and exert their therapeutic effects. ... Read More

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Keywords = Metabolism

A Mini Review on Lactic Acidosis Effect, Cause, Symptoms, Complications, Metabolism, and Pathodology with Its Diagnosis, Treatment, and Preventions

Abstract

The Design of Soft Drugs: Basic Principles, Energetic Metabolite Methods, Approved Compounds, and Pharmaceutical Applications

Abstract