8.1(Q1)
CiteScore
37
h-index

Toothpastes Formulated with Natural Ingredients: Composition, Preparation, and Properties

Document Type : Review Article

Authors

1 Department of Chemistry, Faculty of Natural Science, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan

2 Department of Chemistry, Faculty of Science, Mugla Sitki Kochman University, Mugla, Turkey

3 Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan

10.48309/jcr.2026.561586.1555
Abstract
Recent research highlights the growing interest in including plant extracts in toothpastes due to their antimicrobial, anti-inflammatory, and antioxidant properties. The purpose of this review is to analyze the available data on the chemical composition of plant extracts used in toothpastes, to study their functional properties, mechanisms of action, and potential applications as alternatives to traditional components of toothpastes. This review systematically summarizes data from reputable scientific sources regarding the use of natural ingredients in dentistry. The main classes of biologically active compounds, including phenolic compounds, terpenoids, and alkaloids, as well as their effects on oral health, have been thoroughly studied. The mechanisms of their action, interaction with traditional ingredients of toothpastes, and their influence on the physical and chemical properties of the final product are analyzed. Special attention is paid to the composition and technologies used in toothpastes, which include natural biologically active complexes, as along with considerations of their environmental safety and prospects for further research in this field. The data obtained indicate the high potential of plant extracts as functional components of toothpastes and emphasize the prospects for further research aimed at optimizing their composition and expanding the scope of application.

Graphical Abstract

Toothpastes Formulated with Natural Ingredients: Composition, Preparation, and Properties

Keywords

Subjects


Content

1. Introduction

2. Chemical Composition of Toothpastes

3. Biologically Active Compounds in Natural Toothpastes

4. Methods of Preparation and Physico-Chemical Analysis of Toothpastes

5. Conclusion

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OPEN ACCESS

©2026 The author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit: http://creativecommons.org/licenses/by/4.0/

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Articles in Press, Accepted Manuscript
Available Online from 18 February 2026

  • Receive Date 08 December 2025
  • Revise Date 14 January 2026
  • Accept Date 13 February 2026