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Document Type : Review Article


aDepartment of Pharmaceutical chemistry, Himalayan Institute of Pharmacy Research, Dehradun, (Uttarakhand), 248001, India


The misuses of antimicrobials in infectious diseases have led to the progress of extensive resistance in the infectious organisms. The unsuccessful of accessible antimicrobials to control infections makes it essential to discover alternatives to currently existing drugs. Their connection to infectious diseases and their natural ability increase antimicrobial resistance in microbes, has led to a platforms for research focused on new techniques to control them. In this affords we study, the pathogenicity in many bacteria is regulated by Quorum sensing (QS). The inhibition of QS system may causes the reduction of virulence and protect against bacterial infections. These bacteria rely on chemical communication (or QS) to coordinate activities necessary for their survival in groups by some course of action. Their dependence on QS has made those signaling systems within bacteria an attractive target for the design of new anti-infective agents. Compounds that can interrupt these processes are known as QS inhibitors. The QS is the key regulator of virulence in various bacteria. Various plants extracts and their chemical constituents were showed their effects on bacterial virulence factors by inhibiting of QS genes and QS-controlled factors and effects on bacterial growth. The anti-QS approach has promise in the fight against infections pathogens, thereby making the bacteria more susceptible to traditional antimicrobials. The QSIs may provide the newest weapon against infections involving drug-resistant bacterial strains. These QSIs come from a variety of sources and have a wide array of structures.

Graphical Abstract

Quorum sensing inhibitors: Current progress of the natural antimicrobials


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